Kanye West is featured fighter in Def Jam Duo & Def Jam Control.
Role In Def Jam Duo[]
In Def Jam Duo, Kanye is part of The Throne with Jay-Z. During the Def Jam Takeover dubbed the East Coast Apocalypse, Kanye and Jay-Z saw the scenario as an opportunity to take control and get possession of Def Jam Records. In their version of the ending after defeating Biggie & Pac, they accomplish their goal only to find out that the owner had fired all of the artists essentially leaving the two with nothing but an empty recording building.
Role In Def Jam Control[]
In the aftermath of Def Jam Duo, Kanye is signed to Def Jam Records and signs his prodigy, Desiigner. His crew, though not technically antagonists are against Playa the entire campaign, not specifically siding with The Chairmen but rather trying to take the winning spot and get to The Chairmen himself. He is fought multipule times and is later a boss.